Listen to macbookairman
And if that doesn't work, shut it down, using whatever means necessary. Once it's shut down, press the power button and hold the Command, Option, P, and R buttons, all at the same time. You should hear a second startup boonnnngggggggggggggggg.
Hope this helps.
I have been having a similar problem. I rarely shut my MBP off, but every couple weeks or so when I dojust encountered this a little over a month agoit will not shut down because Mail is still running.