The are reports of some late PC133 DIMMS which don't/didn't come with the PC100 timings. In this case they cannot be downclocked. I don't know how common was this practice, or if it only happened in the lowest tier.
I don't know what would happen if you put this kind of memory in other than the first slot, as the Cube only sets the timings according to what is plugged there. But in this case it shouldn't be memory with more latency than the one in the first slot.