There is technically a degradation, as the audio is compressed further to be sent over Bluetooth. We can't answer if you will notice a diffence, however, as it depends on the speakers. If your speakers are low quality, it's possible you won't hear a difference.
It's similar to the 128kbs MP3 vs Lossless question, there's definitely a diffence, but if you're listening on $10 earbuds it won't matter.