Just installed Sierra and wanted to see what works. So far from my testing the below work for me.
MOD EDIT: This is a wiki post, which is editable by anyone with the appropriate rights. Please update this post with compatible and incompatible apps to ensure the list is comprehensive. For apps with limited compatibility, please include a link to your post explaining the limitations. The lists are in alphabetical order.
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Compatible
1Password 6
2Do
4D v15.2
Accordance Bible
Adapter
Adium (requires manual connection)
Adobe Acrobat Pro 10
Adobe Acrobat Pro 11.0.16
Adobe Acrobat DC
Adone Acrobat Reader DC
Adobe Bridge CS6
Adobe Photoshop CC
Adobe Photoshop CS6
Affinty Photo
Airmail 3
Airy YouTube Downloader
Alfred 3
Amphetamine
Apple Remote Desktop
AppZapper
Atom 1.7.4
BackBlaze 4.0.5.934
Banktivity 5 (formerly iBank)
Bartender 2 (Test Release)
Better Rename 9
BetterTouchTool
BetterSnapTool
BitTorrent Sync
Blackmagic Disk Speed Test
Caffeine
CARROT Weather
Chatology
Checkbook Pro
Chrome 51.0.2704.84
Cloudmagic
Commander One
coconutBattery
Coda
Continuity Activation Tool
CustomMenu 2.12
DaisyDisk
Dark Boot 4.0.6
Day One v2
Deliveries 2.0.1
Discord
Disk Inventory X
Disk Sensei
Disk Warrior 5.0
Downie 2.3.9
Drobo Dashboard
Dropbox
Dropshare
Duet (with iOS 10, although a bit choppy) (DP5 causes app to try & reinstall, won't reinstall)
EazyDraw 8.3.1 (new version)
Elmedia Player
Evernote
EaseUS Data Recovery Wizard
Fan
Fantastical 2
Fetch 5.7.5
Final Cut Pro X (launches but have not used)
FileZilla
Firefox
Flux
Folx Download Manager
Font Book (fixed in second beta)
F5 Big-IP Edge Client (VPN) - Now works in Public Beta 2
GhostTile
Google Drive Desktop App
Handbrake
HardwareGrowler
Hardware Monitor
HoudahSpot 4.2.1
iBackup (for iAccount iOS) - needs legacy java
iBooks
iDrive 3.4.0.15
iFlicks 2
iSkySoft iTube Studio 5.7.1
iStat Menu 5.11
iStat Pro
IVI Pro
Itsycal
Kindle (as of second Sierra seed)
Kodi
LastPass
Letterspace v1.6.4
Little Snitch Nightly build 3.7 (
https://www.obdev.at/products/littlesnitch/download.html)
LogMeIn
Magnet
MacMiner
Malwarebytes
Microsoft Office 2008 (as of 16A294a)
Microsoft Office 2011 (All Applications)
Microsoft Office 2016
Microsoft OneDrive Personal (as of Public Beta 4)
Microsoft Remote Desktop
Mindnode
Minecraft 1.10
Moom
Mountain
MPlayer OSX Extended
MySQL Workbench 6.3.6
Nik Collection
OmniFocus 2.5.3
OmniGraffle 6.0.4 (quite old)
OmniGraffle 5.4.4 (even older)
OpenEmu
Opera
Outside 1.1.5
ownCloud Client 2.2.0
PaintCode 2.4.2
Parallels 11.2.0
PDF Expert
Pinegrow Web Editor v2.9
Pixelmator (Magic Wand causes crash every time it is used, other than that no other observed issues)
Plex
Pocket 1.6.2
Polar FlowSync 2.6.4
PopClip
PrintCheck
Pyware versions 8.0.1 and higher (due to using Oracle's Java and not the old MRJ)
Quicken 2007
Quicken 2015
Quicken 2016
QuickSleep 1.0.2
Quiver 3.0.2
Radio Silence
Reeder
Remotix
ScreenConnect
Scrivener
ScummVM
Shazam
Sketch 3.8.3 by Bohemian Coding
SketchUp 2016
Skitch 2.7.8
Skype 7.30 (274)
Slack 2.0.3
Spark 0.2.3.18
Spotify (although slow to launch and ever the memory hog)
Steam (Code signature error, needs to be manually signed)
Stickies 10.0
StuffIt Expander
Subler
SuperDuper
SyncMate
TechTool Pro 8 & 9
Telegram (As of 6/20 update is unstable:
https://macos.telegram.org)
Telegram Desktop
Text Expander 5.1.4
Text Wrangler
Textual 5
The Unarchiver
Transmission
Transmit
Trim Enabler
TunnelBear
TunnelBlick
Tweetbot 2.4 (though sometimes, tweets appear blank or empty... closing/restarting Tweetbot fixes the issue temporarily.)
Twitter
Vivaldi Web Browser (1.2.490.39) (64-bit)
VLC
WhatsApp Desktop
Yummy FTP
xAct
XLD
Limited Compatibility
Aperture 3.6 (limitations listed in Sierra release notes)
Acrobat Pro 11.0.16 - Will not Print. Fixed in PB4.
CleanMyMac 3 will prompt to install a beta release that supports Sierra (3.5b2)
Fusion 8.1.1 (see
this post)
gfxCardStatus (displays GPU status, but will always force discrete GPU since gfxCardStatus "requires" the discrete GPU)
GIMP (Default language changed, now stops loading)
Hazel (some rules do not work)
Logic Pro 9.1.8 (can crash intermittently)
Screenflow 5 and 6 (opens but nothing shows up when recording)
Simple Comic (will not install latest update but reads CBR files okay)
Sonos (Desktop) - Crashes if left open when computer goes to sleep, otherwise, functionality works as expected.
Splashtop Business (installs but will not always connect to remote computers, closing and restarting the app seems to fix this temporarily)
uTorrent (can crash in certain circumstances)
VM Ware Fusion 8 (Turn of 3D acceleration if you get an "Internal Error" . ** works in Public Beta 2)
Incompatible
Adobe Dreamweaver CS5 (crashes on launch)
Adobe Dreamweaver CS6 (must reinstall Java 6, opens and functions, crashes on Save As...)
Adobe Illustrator CS6 (installer error, if update from prior OS, make work after reinstall Java 6)
Adobe InDesign CC (installs, but has some rendering issues when dragging objects)
Adobe Photoshop CS5 (crashes on close)
Adobe Photoshop CS6 (installer error, make work if update from prior OS)
Apptivate
AVG AntiVirus (doesn't open)
AVG Cleaner (crashes at launch)
BOX Sync (brings up Console, floods with errors, doesn't work at all)
BusyCal (crashes at launch)
Carbon Copy Cloner 4.19 (installs and opens for use but does not actually backup)
CCleaner (does not open)
Citrix Receiver
Contacts (Apple's Application) Crashes FOR SOME at launch
Disk Warrior (launches and works for a while but crashes in the end before replacing the rebuilt directory)
EazyDraw 7 (crashes at launch)
EtreCheck (crashes during scan)
Final Draft 9 (crashes at launch) (Update to 9.0.9 fixes problems)
Fluid (any apps made with Fluid crash on startup)
Freemacsoft LiteIcon 3.6.3 (Error message at launch even when SIP is disabled)
Greek Radio (icon has slash through it, Sierra throws error when launching)
Identify 551
Karabiner (needs major changes, not coming anytime soon)
Little Snitch 3.6.3 (see nightly build instead
https://www.obdev.at/products/littlesnitch/download.html)
Logitech Control V3.93 Doesn't recognize my Logitech Performance Mouse (Logitech Unifying Software V1.2.315 works). What this means is that my Logitech Mouse is Recognized, but just the left and right buttons work along with the scroll wheel. None of the other buttons can be programmed Because Unifying Software does not recognize the mouse.
Maintenance (crashes at launch)
Onyx (crashes at launch)
MPlayerX
Movist ( crashes after some minutes)
Pulse Secure 5.2r2 (backend dsAccessService seg faults when run)
Pyware versions 8.0.0, 7, 6, and lower (due to Apple's MRJ Java--not able to be installed on 10.12)
Quicken Essentials for Mac 1.7.4 (icon has slash through it, Sierra throws error when launching)
RapidWeaver 7 (Opens projects and appears to work but crashes when previewing Site)
Razer Synapse 2.0. (Loads but can´t detect device)
Safari Technology Preview 9.1.2
Seil (needs major changes, not coming anytime soon)
Scansnap Manager (crashes while trying to save the PDF)\
SIMBL (SafariStand etc.)
Splashtop Streamer (installer will crash on fresh installs, but will stream if previously installed on El Cap then updated to Sierra)
SyncTwoFolders 2.19 (Crashes after selecting destination or target folder)
Ulysses (crashes at launch)
Yosemite Disk Utility patched for El Capitan (crashes at launch)
Microsoft OneDrive (Crashes at Launch) -- works for me -- works as of PB4
Western Digital Disk Tools (Complains about needing to be launched from Applications folder)
WhatsApp Desktop (always recommends moving to Application folder when it is already there, and will lose login details prompting QR scans every time OS restarts) -- ChitChat works for me
WriteRoom 2.5.1 (marked as incompatible)
ZenMate (makes initial VPN connection then disconnects)
