I have Auxo + Zephyr but you can check just a few posts behind the amount of tweaks/apps I have installed and I get nothing but the regular draining use.
I have DFU restored my i4S and my i5 many times, I mean it! Over 10 each, at least, always trying combinations of different tweaks and always starting fresh with a new restore to leave no doubt something was left behind still draining my battery. I must say I found the right combination for me with no abnormal loss at all!
I have so many things disable on my phone, weather for example is one, stuff always checking for my location, etc. Plus I don't use my phone as my computer replacement when I'm near it. I have seen so many people using both at the same time. Also, I don't use Facebook everyday, once every 3-4 days and only on my computer, twitter everyday on my computer, mostly at night on my phone.
It is all about the amount of tweaks you use, if there's conflict or whatever, and the use you have of your mobile. I just don't accept that the app X or Y drains more the battery than others because I have proof that the app/tweak itself doesn't! (Unless there's a memory leak or it is conflicting with other) I tested the major ones and I can tell.
Oh, and trust me, I'm an engineer.