No.
Apple has made it pretty clear that OS X is going to remain fairly evolutionary from this point on. The UI may receive a refresh, but that seems unlikely. The last time the UI was overhauled, it took 4 years: 2007 was Leopard's release, and only in 2011 was it changed with Lion, which was again, very evolutionary. Since it's only been two years, why would you expect that next year there would be a major user interface change?
Besides, it's not like iOS, where Apple can force developers to refactor and redo the UIs on their apps to match. The Cocoa APIs have been steadily increasing, but have always been changing ever so slightly each revision. Apple can't risk breaking compatibility with tons of old apps, or creating a dichotomy between old and new like Windows 8.
We may see some new icons next year, or maybe a few more hints. But my theory is that in around 2 years, OS X will look and work much the same as it does now. I don't know why people clamor for change for the sake of change; OS X already looks pretty fresh and works extremely well. iOS was dated, clunky, and in need of an overhaul, which is why Apple changed it.
I don't see them doing the same for OS X, especially with Ive boldly claiming in the 5s promo that "we don't believe in rampant innovation for innovation's sake."