I've been using this resolution for some 8-10 hours per day since 2014. No eye strain, sit from a normal distance from my screen (25-30"). But this is my reasonable limit, tried going to the next step up and found myself leaning in closer. Also to note that I *don't* make any OS or font elements larger anywhere. In fact, I slightly reduce the default font size in my current editor (VSCode), but in general everything is left at the default. The aim is simply to increase usable desktop.
Now let's go back to the 90s and dealing with CRTs in a well lit office... that was eye-strain city
. Also about 15 years ago I briefly had a 15" Dell Laptop at 1920x1280 and returned it as it was hard on my eyes. I surmise this smaller screen works where that didn't due to using HiDPI at an overall much higher screen resolution with a much higher quality screen, font aliasing, that allow my eyes to resolve detail with much less effort.