Always with a case, but no screen protector.
I never scratched an iPhone screen since the original iPhone. Also, I tried screen protectors every once in a while, but was never satisfied with how they degrade screen quality a tiny bit, and also the "sliding feeling" on the screen isn't as good as without screen protector.
This year it's even worse: the screen protector also protects the front camera, making the quality worse by definition. I don't want some third party glass to cover the iPhone camera.