2 signature: a 'new' message and a 'reply' signature

Is it possible to have 2 different signature. I used to be able to do it on my old pc where i had one signature for new messages (with company info, weblinks, etc) and one for when replying to emails (with just my name and phone number).

Would be great to do this if possible

 

i'm using mac mail. Setting up different signatures isn't the problem. I want to know if it's possible to have 2 different signatures for the same mail account so that one is only used when i'm composing a new mail, with a long signature containing my website links, client list, etc, but then to have a second signature that is used on the same account for all replies i send which is shorter to avoid OTT email trails,