I'll second that. I've never used it on a Mac, but on a PC it's just the pits.
Sophos do a Mac version of their scanner to the best of my knowledge... I'm not using anything on mine though, it really does seem pointless. If there ever was a serious threat then I'd imagine the press will make a big deal out of it like they do already, unlike Windows viruses which are two a penny.
If you really must Intego isn't bad, though it seems to have problems with turbo mode, without its fine and still pretty fast (compared to Clam XAV and Sophos which want to take all day, literally)
If you must run AV software to prevent you from unintentionally passing along viruses to your Windows using friends, then look no further than the free - OK donationware - ClamXav. It is all that you will need.