I got mine last Friday, initially I hooked up one of my Dell U2518 via HDMI (my USB-C-to-mDP adapter was delivering the next day). Worked great, slept, woke, restarted, etc., all just fine.
Got my adapter in the next day, used the existing mDP-to-DP cable already connected, both displays fired up, needed to swap the dual orientation, everything seemed to be GTG ...
... but then through a few restarts / sleep cycles, the HDMO display didn't come on. Everything was set to auto input select, tried manual, don't think that worked (you start getting too many variables). Anyway, I figured I'd give MST a shot, the displays are DP1.2, MST compliant, I saw the 2018 Mini was __supposed__ to support it.
Enabled MST on Display 1, which is connected display >> DP >> mDP [adapter] USB-C >> Mini
DP OUT from Display 1 >> mDP in on Display 2
The proper setting according to the docs is MST on first display, off on the daisy chained one ... but tried all combos, the only thing I could get was a mirrored display
So I swap back to HDMI ...
... and * poof *, no more issues. I've restarted, cold shut down, user induced sleep, normal sleep, 15 minutes, or all night, it +always+ wakes back up. There is a touch of latency, like the DP/Display comes on in 2-3 seconds, the HDMI is like 4-5, just a couple of seconds behind.
So weird, but great. I mean, I was going to just order another adapter and run both off USB-C, but I'm happy for now
Maybe the something got set differently with the input type select (like going from auto to manual?), MST shouldn't have any effect, but it's still enabled on my DP connected display ... [?]