I am in the process of transferring to the Affinity Suite but still reference the CS6 Suite regularly and Lightroom 6 is my Image Organization software.I've tested several 27-inch 4K displays.
All UI scaling options in MacOS will give you sharp text and UI elements.
However with some graphic design software, e.g. Photoshop, Affinity Photo, you will not get true 1:1 pixel representation at 100% zoom with certain UI scaling options.
Depending on your work, that may or may not matter. For graphic designers, I think it matters.
That's why I'm sticking with my 27-inch 1440P display. If I want to upgrade, I'll go with 32-inch 4K (used without UI scaling), not 27-inch 4K (used with UI scaling).
The other problematic display size and resolution combination is 16-inch and 1440P.
I'm quite used to my older U3011 @ 2560x1600. Would you happen to know how the UI scaling for 4K+ works for software like CS6?