How much RAM in the Mini?
How much SSD space?
If nothing seems to be helping, you could try this:
You will need an EXTERNAL drive of some sort (SSD, USB flashdrive, HDD) -- large enough to hold her account files.
Then...
Log her out of all the online stuff (iCloud, etc.)
Then...
Copy your wife's user account folder to the external drive.
Verify that "everything is there" (on the external drive).
Then...
DELETE your wife's account on the INTERNAL SSD.
Don't archive it -- delete it completely.
Then...
In users and groups, create a NEW [empty] account for her. Just a username and password for the moment.
Then...
Connect the external drive.
You will need to overcome permissions problems by doing a "get info" on the drive, unlocking the lock at the bottom, and then put a checkmark into "ignore ownership on this volume".
Now...
Start copying things back over, a little at a time. Example... do the pictures folder first, reboot, let her log in and see if things are better.
The idea is to "rebuild" her user folder from scratch, and hopefully you will discover (or simply leave behind) what was slowing things down.
IMPORTANT note about copying from one user folder to the other.
You CANNOT copy "the top level" of folders -- the ones specifically named pictures, movies, music, downloads, documents, etc.
HOWEVER -- you CAN copy what is INSIDE OF these folders (that includes both files and folders).
Again, deleting and then rebuilding the user folder can be tedious, but [also] again, it may work when nothing else does...