for DUAL channel to work (a requirement on a mac pro, incidentally), you need matched PAIRS.
for QUAD channel to work (not a requirement on a mac pro, but an option), you need matched SETS of either 4 or 8, which obviously are multiples of 4.
Now, back in the old days of single vs. dual channel DDR RAM, I did some tests and benchmarks of memory performance and system performance i general with my PC that had a dual-channel BIOS setting that could be easily adjusted.
I had a matched pair in the machine, and ran it on dual-channel mode, and compared to the same setup with single-channel mode forced, it did 5-10% better in memory-specific sub-tests in benchmarks. If you look at the entire system's performance, even in a memory-hungry and memory-intensive benchmarking app, you'll find that the actual system performance increase is less than 1%, all other things being equal.
Actual everyday system performance will be even less of an increase.
If you are going to need more than 14GB of RAM, then it makes sense to pull out the 1GB chips and replace them with all-matching RAM. Otherwise I don't think you'll ever see a real difference, unless the work that you do is writing/debugging memory benchmark software. That's probably not any of us. For most of us, having more RAM is more important than having marginally faster RAM. running in quad-channel doesn't double the speed or anything.