No keypad = easier mousing
I recently bought a new iMac without a keypad. I was skeptical at first, but after a few weeks I have to say I prefer it this way. Yes, I miss the numbers occasionally, BUT my mouse now sits much closer to my body. This results in less strain on my wrist while mousing, and less distance to travel for my right hand between keyboard and mouse. Since I use the mouse a lot more than I ever used the number keys, I think it's a worthy trade-off. Something to think about for anyone whose body is starting to complain about the long hours we spend sitting at our computers.
Plus, the reduced footprint on my desk is nice too.