They'll all fail
A couple years ago I bought a Maxtor that failed just after its year warranty was up. So I bought a Western Digital... that failed just after its warranty was up. So I wised up last year and broke my poor little piggy bank and got TWO hard drives, this time Lacies. Both drives' USB ports failed almost immediately, but that was ok because they still each had 2 Firewire ports. And now (this month) now both drives died completely. A lot of the data was also on cassette tapes, videotapes, zip drives and floppies (remember those?) almost none of which are readable any more, and in any case I no longer own vcr's, zip drives and floppy drives.
The one time I actually had everything multiply backed up, the entire lab burned down. (no joke. Univ. Washington 1996 biology dept. fire.) The guy down the hall left a hot plate on. It was the last year of my Ph.D. I had to stay a whole nother year to re-do all my labwork. Then a year later came the SECOND fire. Another lab, another hot plate. *sigh*
A lot of the advice for protecting data boils down to "buy a lot of expensive equipment and spend weeks and weeks moving stuff around" which always makes me wonder just what kind of budget the hard drive manufacturers think we've got.... and what kind of life to have that much time free.
I have a double strategy now:
(1) I back up my current projects - the ones where, if I lost the data, I'd lose a job or a publication - on 2 computers, 2 flash drives, 2 ipods and a website. I rename files constantly so as not to overwrite stuff. My computers are littered with extra backup folders. Since the fires, I also put major completed projects on a private website, always keep stuff in 2 different houses and also give a copy to a friend in another state. (And I cruise my lab every night and unplug every hot plate and water bath, you better believe it)
(2) and when all that fails, I don't much worry about it much anymore. Whatever you lost, dearly beloved photos of your deceased pet rabbit, your rare Hungarian trumpet-fiddle, your priceless field recordings of Rio Carnaval bands, the original data from your Ph.D., whatever it is, nothing matters as the fact that you are still alive. It's funny, after 5 major losses, now when the second Lacie died it didn't even really bug me; it was just like "Huh, the second Lacie died and all my data is gone again. Oh well!" I guess I've gotten used to having an annual data purge.
Anyway I am taking on a second job this month to buy a new Seagate. I'll write back with an update as soon as my new Seagate fails.