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First there are only 1GB, 2GB and 4GB sticks available. It seems you cannot mix third-party 4GB sticks with other sizes but I don't think anyone has reported problems mixing 1GB and 2GB sticks. If you did, I'm pretty sure the two 2GB sticks should be in slots 1 and 5 with the 1GB sticks in 234 and 678.

Hmm, just saw this. I ordered a 2008 3.2 GHz Octo that has 2GB of memory and have also ordered 2x4GB RAM from Crucial. Will I be able to mix the 4GB sticks with the existing RAM?
 
Hmm, just saw this. I ordered a 2008 3.2 GHz Octo that has 2GB of memory and have also ordered 2x4GB RAM from Crucial. Will I be able to mix the 4GB sticks with the existing RAM?

My post you quoted was discussing the 2009 Mac Pro which has different RAM requirements than the 2008 and previous.
 
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