If your situation requires you to run a 3rd-party antivirus app:
ClamXav is one of the best choices, since it isn't a resource hog, detects both Mac and Windows malware and doesn't run with elevated privileges. You can run scans when you choose, rather than leaving it running all the time, slowing your system. ClamXav has a Sentry feature which, if enabled, will use significant system resources to constantly scan. Disable the Sentry feature. You don't need it. Also, when you first install ClamXav, as with many antivirus apps, it may perform an initial full system scan, which will consume resources. Once the initial scan is complete, periodic on-demand scans will have much lower demands on resources.
Sophos should be avoided, as it could actually increase your Mac's vulnerability, as described here and here.
iAntiVirus has a bogus malware definitions list, making their detection accuracy untrustworthy. They also make inaccurate claims about the existence of Mac malware, in order to hype the need for their product. This post will give details.