Don't forget to leave the system on from time to time, so OSX can do the house keeping for you.
Try to avoid all those so-called utilities, they only good for lining the MacOS trash and thinning your wallet.
What do you mean "leave it on." What does this do and how is it helpful?
Your Mac has some little maintenence scripts it runs in the middle of the night. Open up your terminal and type in "man periodic" (without the quotes) and hit enter to learn more about them. If you want to check whether they are running on time, use this command:
ls -l /var/log/*.out
Don't forget to enter after typing that in. It will show you the time they last ran. If any are off, you can force them all to run manually with this command:
sudo periodic daily weekly monthly
You'll need to type in your password, and you may get a warning about the "sudo" command if you've never used it before.