I test my new MacBook pro 2018 last night with 16gb of ram and the LG 5K with all the USB-C ports used and it worked pretty well. Can't comment how dual monitors will perform but I think it will drive a single LG 5K monitor with no problem.
To answer your questions on performance with an eGPU, everything feels more responsive but I can't say it's necessarily worth it with a single LG 5K monitor unless you're doing video editing or gaming. On the MacBook pro 2016, it provides a clear difference in performance but the performance ceiling is now clearly raised with the 2018 MacBook pro so the performance difference is much more subtle.
I ran a quick torture test of running a 4k HDR 60 fps youtube video clip on chrome while running a time machine backup in the background on both wifi (more resource intensive) and physical ethernet. Also played around with Capture One Pro with and without egpu. The MacBook Pro 2018 without egpu handled the youtube test quite well. Capture One is a little bit laggier than with the eGPU but still very usable.
Overall, i'm a bit on the fence with respect to keeping the egpu but leaning towards keeping it since it does add a dedicated video card with 8 gigabyte of ram to my system and a better USB-dock than the LG 5K monitor by itself. I figure it's good for at least 3 years or until Apple replaces Thunderbolt 3 - it'll likely outpace integrated GPUs for a while even if better video cards come out.