I'm a machinist and need the best protection I can get. I'm very happy with the defender. I don't use the belt clip and don't mind the bulk in my pocket. My only issue is I wish they had screens to cover the mic and speaker areas. I tend to get debris build up there.
Although I'm with AT&T I use Verizon screen protectors with my Defender because they're the only protectors that can fit with the Defender. Protects the camera with larger camera slots and front speaker/proximity sensor area.
I used to use it daily, but I don't use it anymore since I don't feel that I need all of that protection. The case adds a lot of bulk, but it really makes the phone much more resistant to drops.