Nah... only tried with my girlfriend's old Net-MD. And the only way to use that is through to run OpenMG Jukebox through Windows. It works, and I'm using that word in the broadest possible way, through Parallels on my MacBook, but when we tried using Virtual PC on her iBook Windows never recognised the MD (ironically both Macs recognized the Net-MD and identified it perfectly, but there's no OpenMG Jukebox substitute for the Mac 🙁).
Don't know if you can use newer MD players. My advice: Sell the MD and get an iPod. Seriously. 🙂