I have an intuos4 medium and while i used to use it as my primary pointing device (probably due to novelty) i got tired of sweating on the thing and wiping it down every few days. I even got one of those smudge guards to prevent the sweat factor, as i draw a lot on the computer... I ended up going back to the mouse for non-art things. I later got the trackpad as space was limited on the desk (what with that intuos in the "mouse space"
I used a Wacom Graphire Bluetooth tablet as my main pointing device for a couple of years, except when playing games. I only really stopped once I added a third screen which made the tablet impractical to use due to the mapping of the screens to the tablet. I just never got back into the habit of using the tablet as my main pointing device after that.
Nowadays I'm on a MBP and mainly use either the built in touchpad or a Magic Mouse.