I used MacPorts on my previous Macs but on my new home and work machines I have tried only using Homebrew and so far I'm very happy after about 5 months. These are development systems and so far everything I've needed has been available and haven't had anything not work.
The biggest difference is that I measure installs in minutes or seconds rather than tens of minutes or hours. There's something to be said for simplicity, and so far Homebrew seems to be simpler than Macports. Time will tell if it stays that way.
I certainly recommend giving it a try.