Anyway to transpose mac application to external drive?

If the application is an -Apple- app, moving it to another location (other than the default location in the "Applications" folder) may result in problems both in running the app, and updating it.

If the application is a "3rd party) (i.e., non-Apple) app, you can probably move it wherever you wish. Again, you might have problems when you attempt to update it.

The best way to find out, is to try it.
I'd suggest going "slow and easy" -- move an app at a time, see if it runs, move the next one, etc.

 

A possible option might be using Carbon Copy Cloner with an external drive. This will give you an exact copy of your internal drive and possibly allow you to remove the apps you are not using on a regular basis from your internal drive. You could then boot from the external drive with CCC and run the apps from it.

But as Fishrrman stated, be careful and slow about doing it so as to not mess anything up. Have never tried it myself. Maybe someone on the boards has and can add further info to assist to with it.