Here is my experience of using SMR HDD for backup.
HDD:
Western Digital My Passport 5TB WDBPKJ0050BBK-WESN 2.5" USB 3.0 External Black.
File system:
APFS (case-insensitive, i.e. default).
Backup:
2.5T of photos, videos, movies, books and small source code / lib files
Backup was made during the recent week, by means of copying portions of data in ~5-8 steps from my MBP (2018, Big Sur 11.5.2). The HDD itself was absolutely new, it was never attached to any computer besides the MBP. Upon detaching the drive, I've always waited till the drive have been ejected from Finder, however I've noticed that this HDD was almost always spinning after ejection, and thus sometimes clicked when USB detached. Also, there was recently a single occurrence of a shutdown/crash of MBP, when I once attached both of my external HDDs (not very long before The result).
The result:
when attaching the HDD, the message is displayed:
macOS can't repair the disk "My Passport 5TB".
You can still open or copy files on the disk, but you can't save changes to files on the disk. Back up the disk and reformat it as soon as you can.
Troubleshooting:
1. Disk Utility's First Aid process fails, first errors are:
error: (oid 0x402) apfs: _omap_lookup_obj(0x402, 0x0): No such file or directory
Volume superblock is invalid.
2. DriveDx's SMART status for HDD is OK regarding all parameters.
3. I've decided to re-format HDD from APFS to HFS+, and try again. In a case of issues, I will switch to a new HDD, presumably non-SMR.