Another poster has just reported being infected despite having Sophos installed. I don't think I'm qualified to say whether antivirus software is advisable or not, but I believe many antivirus users have something in common with many Mac users: a certain tendency to feel overconfident about their protection. Besides the need of a faster response to threats, that's where I think that OS and security software vendors have failed: in educating their users about the limited extent of their security and the part of responsibility that still resides in the user.
Regarding the linked post, that situation is very strange since F-Secure says he is not infected and in manual check he doesn't have files related with Flashback but Kaspersky seems to have his UUID. Its most likely false positive since he doesn't have the Flashback files. Anyway, Kaspersky app was pulled due to problems so I'm betting its false positive on their part.
Regarding the need to run anti viral software; I don't think there is a one right solution. It depends on user requirements. One might be safe without any monitoring or protection while other might be asking for trouble even with full virus protection and outgoing traffic monitoring.