You've gotta watch this video. CUDA is the next step to transform desktop computing. Intel is working furiously to catch up to nVidia. Microsoft is also working very hard and appears ready with a ground breaking HPC server 2008.
Really folks, watch this video to understand how HPC has the capacity to change lives in ways we've never understood. Every wild-ass student or scientist likely can afford his/her own supercomputer in a few years. That's what its going to take for real breakthrus in some 'in the box' constrained research areas.
BTW: This video is (intentionally I think) one of the most borderline hilarious nerdy, geeky things ever. But for those whose lives are saved by their tomo process finding a cancer etc. it is also over the line miraculous.
http://www.youtube.com/watch?v=DnIvodB2RzU