Help required. I've been running OSX 10.6.2 without any problem for the last six months until today....Now when I try to run applications (other than Safari which is working slow, but otherwise ok) the application icon will appear in the dock for 2-3 seconds and then disappears without opening the program. I'm not aware that I've added or changed anything that might have triggered this problem. I can however open the applications without any problem if I boot into safe mode. I've tried more than one user profile, disk utilities, resetting PRAM, running Onyx maintenance utilities etc. I'm at a loss as what to try next !