I actually had a l-o-n-g talk with MOTU and it does seem that it *is* an issue. The work around is to boot the computer up1st, and then turn on the interface. I'm still having some issues with individual samples (e.g. female voice in Sibelius, a specific note in Symphobia), but if I do it in this order I don't get the double audio driver icons, and that means I don't get the digital clipping or no audio issue. Hopefully there is a fix in the works. I'm going to see what happens, if this is indeed a fix/work around. It worked today. But, tomorrow is another day!