I just updated to iOS 4.2 and I had a big issue. It is not really anyone's fault and the GM build is very solid. But, I just had an unexpected problem. itunes 10.0.1 will not sync with iOS 4.2, period. Once you unplug it, your iPad's video and iPad will show error message saying, "Sync" Bottom line, you will not be able to use your video and ipod app on your ipad. If you upgrade your iPad to iOS 4.2, then I suggest you wait or find a way to get itunes 10.1. Just heads up for those of you who are upgrading or thinking about upgrading. Good luck.