Hmm. That's a tough question.
A friend of mine was able to go to Best Buy on his lunch break and get the iPad 2 on its launch date.
This is in Seattle. Not sure about other stores elsewhere. I think the majority of people would buy it at the Apple store instead of Best Buy.
I was asking myself if I wanted to go to Best Buy, too, because there's little to no wait, but I told myself that I'd rather get it at the Apple store because it's more official and because of the experience.
Then I kinda going back and forth on whether I wanted to buy it in the store or pre-order on Apple.com. I love going to the Apple store and making my purchases there. It was a tough decision, but I ended up pre-ordering online on the 7th and have it delivered to me on the 16th.
I would've pre-ordered and waited in line at the Apple store to pick it up, but then I didn't want to be waiting long and I think you would have to pick it up on the 16th otherwise you'd have to wait a few weeks. Not sure how that works.