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I'd say Vice City Stories. I was a huge fan of the Xbox version, and whilst not as good, it's still an enjoyable and fairly expansive game. I'd say Metal Slug but it hasn't got the save anywhere feature the Wii has, and when each game takes 45-60 minutes to complete it's sorta needed for a handheld 😱
 
If you like sports, definitely get MLB:The Show (either o6 or 07). It's the best baseball game out for any system, by far. Hot Shots Golf is also a great portable game.

If you don't like sports, LocoRoco is fabulous.
 
what kind of games do you like?

Metal Gear Solid <--probably the highest rated
Ace Combat
Syphon Filter
Daxter
Ratchet and Clank
Killzone
Socom
Metal Slug
Grand Theft Auto
 
It really does depend on what kind of games you like, but here's my .02

-Burnout Legends
-Metal Slug Anthology
-Lumines
-SOCOM
-MOH: Heroes

Racing games work really well if that's your thing and so do puzzle games. Most shooters haven't really impressed me that much but Medal of Honor and Socom were really good.
 
i think loco roco is the best game for the system. it's original in gameplay and style. it isn't a derivative of a franchise that you can play on a console, and it's incredibly fun.
 
it's original in gameplay and style.

I'll give you style, but gameplay?
boxart_eur_yoshis-universal-gravitation.jpg
 
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