I hesitate to give advice because I don't know what I'm talking about, but I have always read that when interleaving memory they should be matched pairs.
Granted, in a typical PC the DIMM slots are laid out such that you need to alternate the sticks in order to interleave matched pairs. In a PC I would definitely do 4,1,4,1.
But in the MP the slots must be laid out differently. The table I provided above from Apple shows the two-DIMM layout with both DIMMs placed adjacent to each other, not in alternating slots like you would in a PC.
In any case, I also have 10GB of RAM and mine are installed 4,4,1,1. Whether this is ideal or not, I don't know. I do know that all 10GB are recognized and working.
P.S. Your signature is out of date. 🙂