I don't think bootable is so much important now.
all Mac has built-in netboot feature, so you can boot from another Mac via ethernet, or you can just restore the whole system via net restore...
really, when you have a computer failure, you CAN boot from your external drive, but you WILL reinstall your system anyway, you can't boot from external forever right?
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most NAS now have RAID, so it's pretty solid again drive failures, as for NAS failure, you just need another similar NAS and put the drives back in... I'd say NAS is pretty safe (except again fire/flood/earthquake...)
of course the best way is back up to a NAS, and back up NAS to cloud. couple advantages:
1. your internal network is usually faster than your internet speed (unless you have symmetric gigabit fiber, like me, ha ha ha ha ha ha ha ....) so if you back up from your computer directly to cloud, it could take days, weeks to finish, and during this time, you are NOT protected, and you will NOT get incremental backups for this period of time. plus you need to keep your computer running. but if you back up to your NAS, it could just take couple hours, and after that, you are still backing up to your NAS incrementally, you loose nothing. and NAS will be uploading those backups to the cloud in the background. it doesnt matter how long it takes because NAS are designed to run 24/7, and it won't be any longer than how long it would took if you were uploading from computer.
2. many good cloud backup services charge on a per-computer basis. which means if you back up from your computers directly, and you have two computer in your house, you need to pay extra for the second computer. but if you back up everything from all your computers to your NAS, and backup from your NAS to cloud, you will always be paying for only one computer.