Not necessarily. The primary space eaters are movies, music and pictures. With lots of picture taking with some recorded HD videos sprinkled in you can fill up quite a lot of space. A bit of movie collection to keep locally can eat GB like nothing.
Statistics sounds like a lot of data but that is usually in fairly compact data base form. Even if it is a lot is probably only a couple of GB, something you can hit with a couple of HD videos easily. It takes a lot of data base entries to take up the space of just one 1h HD video.
Oh, I completely agree. Video/Audio/Games is what takes the most place on my machine. I do not have a super-extensive music library and I don't take that many photos - my iTunes and iPhoto libraries combined are just around 20GB. I am just saying that with a little bit of discipline this is not really a problem. For example, I have around 50Gb worth of series on my machine - but these are series that I currently watch. The rest is on an external drive.
P.S. The biggest data set I work with is the Google corpus, which is 220 GB compressed. Of course I don't work with the full dataset on my machine - the big analyses are run on a university cluster. They can also take hours and even days.