"I have unresponsive USB drives now. I've tried all the usual stuff like repair permissions and such. Nothing works. The wireless mouse and wired keyboard are both not making a connection. I'm afraid one of the ports is fried. Before I take it in and spend probably lots of money do you think reinstalling OSX 10.5 will fix the USB problem?"
Here's a thought:
Do you have the original System Software DVD that came with the Mac, the one that is capable of booting it?
If so, try this:
Disconnect ALL USB devices, EXCEPT your keyboard and mouse. (I'm assuming the mouse, although wireless, has a "transmitter" that plugs into a USB port?)
Try booting from the System DVD
Does the Mac boot?
Once booted, do the mouse and keyboard work? Can you move the mouse pointer? Can you enter text from the keyboard?
If the answer is YES, this indicates that the USB port that your mouse and/or keyboard is plugged into is good. NOT a "hardware problem".
If your mouse and keyboard are working, you might try opening Disk Utility (while still booted from the DVD), and doing a Permissions Repair on the internal drive, and also doing a "Repair disk" routine.
Next, do this:
RESTART and boot from the internal hard drive with just the mouse/keyboard connected.
Do the mouse/keyboard still work? If they DON'T, then perhaps there is something wrong with your System on the hard drive (since you verified that your port(s) is/are ok while booted from the DVD).
Other thoughts:
- While booted up from the System DVD, you could attach your USB external drives one at a time, and see if they are readable and repairable by Disk Utility.
WARNING WARNING WARNING
You DO NOT want to re-initialize them!
Just check them out, and repair them if necessary!