Create 2 4GB disk images with disk utility. Mount the .iso in OSX (just double click it), copy the files to the 2 disk images. Burn the 2 disk images with disk utility. If the iso you're backing up is bootable then you'll loose this if you do this.
This of course assumes you can split the files up into two chunks like this. If not you could do something with 'split' via the terminal to break up the iso into 2 chunks, burn each chunk to a dvd, then 'cat' them back together again when you need the original file.