Yes it is possible to use "best for display" or retina. I have a 4K dell p2715q with the mac pro 2013 and can do this. I personally use 2560x1400 for day to day use.
Oh, right ... unless this is a Mac Pro 2013 with Yosemite I can't say how good 4k works. With the new mac pro and a 4k display in my 4 weeks of use I haven't had a single issue (personally). Good luck.
Yes it is possible to use "best for display" or retina. I have a 4K dell p2715q with the mac pro 2013 and can do this. I personally use 2560x1400 for day to day use.