Could you safely jump from 7.0 to 8.0? Yeah. Apple hasn't been requiring interim updates for iOS ("To update to 7.1.2 you must first install 7.0.1, 7.0.2, 7.1, and 7.1.1..." Not.). You can update to the latest version, from any older version, so long as your equipment is compatible with the latest version.
It's working the same way on OS X these days, too. You can go directly from Snow Leopard to Mavericks, skipping both Lion and Mountain Lion.
Of course, "Is it safe?" is a loaded question. I've been beta testing software since the mid 1990s, so I don't worry about the x.0 release. If there's a problem, it's most likely something I can deal with. If you'd rather wait until it's been "perfected," then by all means, wait for 8.1, 8.2, 8.9.999...
But from the standpoint of overall safety? Don't do a software update unless you know you have a good backup. If your backup is in iCloud, go into iCloud settings and 'Backup Now' before you update. Updating via iTunes/computer tends to be faster than wi-fi updates. Plus, it automatically creates a backup, and also avoids most "insufficient space" problems. It seems a bit old-fashioned to me, but there's nothing wrong with that.