Not really. I have an iMac and MacBook Air, but I mostly have them running Windows with bootcamp, and rarely boot into OS X. I have no problems flipping files between my iPad/iPhone and my "Windowed" Macs.

iCloud for Windows will even sync iOS Safari bookmarks with Internet Explorer, and I think Firefox. You can also set up PhotoStream on Windows. Dropbox works great at transferring files between iOS and Windows, though I also use an app called File Browser, which lets you transfer files to and from iOS devices over a wifi network. The only weak point is that iTunes for Windows is clunky and a pain to deal with -- very slow to start up, and not very stable with wifi sync and downloading stuff. However, since iOS devices are now pretty much PC-independent, you'll need to use iTunes only rarely. There are of course a few other stuff that are better integrated on OS X, but nothing that is a deal-stopper, IMO.