Funny...I just bought a brand new Macbook Pro (base model 15" with the 2.2) two days ago, and one of the first things I did was start a new Civ IV Warlords game. I was upgrading from a G4 Powerbook, so I was interested to see how much better the game worked on a system with decent specs.
It worked fine. No noticeable glitches or oddities, no crashes, and the game speed was nice and smooth (even in later times when it would get bogged down on my old machine).