OS X 10.5.6, Intel, with the latest version of Clam. When I try to update virus definitions, I get the "Error 48, can't read database from remote server" error. It's not a router issue, and my incoming and outgoing firewalls are fine. No error messages in Console or the system log. I haven't changed any system settings, it just started showing this error about a week ago when I tried to update with the previous version of the Clam engine, I updated to the latest version, and it's still giving the error. As far as I know, the remote database server is operating correctly.