AppZapper, AppCleaner, CleanApp, TrashMe, and similar apps do not do a thorough job of removing all files/folders related to deleted apps. I tested several of these, using Skype as the app to be removed. Of 17 items to be removed:
AppZapper missed 13 items
AppCleaner missed 11 items
AppDelete missed 8 items
Hazel missed 9 items
I also tested AppTrap, CleanMyMac and a few others, but don't recall how many items they missed. All left files/folders behind. In most cases, they remove .plist files and a few others, but leave behind much larger files and folders. (you will find a discussion of these tests in the thread linked below)
One app that I would
not recommend, based on the number of complaints that have been posted in this forum and elsewhere, is CleanMyMac. As an example:
CleanMyMac cleaned too much
The only effective method for complete app removal is manual deletion:
You don't need "cleaner" apps to keep your Mac running efficiently. Mac OS X does a good job of maintaining itself, without the need for 3rd party apps. Some have successfully used apps like
Monolingual to remove unwanted languages and architectures to free up drive space.
Be aware that extreme caution should be exercised when using such apps, as deleting certain languages or architectures can create significant problems. At best, deleting these things may buy you 1-2GB of drive space, but will not improve your system's performance. If you're not certain about what you're doing, don't delete anything. The small drive space savings are not worth the risk of potential problems.