Is it a 15" Classic Pro? If so, there is a small plastic retaining clip inside on the underside of the computer that helps hold the bottom case plate flush. For whatever reason, I suppose to provide some give for heat expansion, it isn't 100% tight. When you pick up the machine, or apply other small amounts of torque you can sometimes hear it click or move a little. My 2010 15" has done it since the day I got it.
I read about other people experiencing it and a few months later while upgrading the RAM, I noticed the clip right the ram slots and battery connector. Sure enough, it had a little give and that is about where the sound comes from. I still notice it all the time, but it doesn't bother me. Especially since I put in an SSD last year and know it is not the HDD. ;-)