Telekinesis is the way to go. It is unbelievably easy to set up, and once you have it on your machine, you can do lots of different things with it. I use it to stream media to my iPod Touch (even movies stream great), use my iSight camera, remote control your iTunes, browse and open files, launch programs, etc.
Additionally, you can use Automator to create tons of automation scripts to add more control. I built scripts to control system volume and to shuffle specific playlists from anywhere in my house. Anyone with any Applescript knowledge could really do amazing things with this.
It isn't perfect, and maybe it should be seen as a supplement to something like VNSea, but I use it all the time and I fully expect a LOT more functionality in the future.