Could I have different System Preferences when external monitor is attatched?

Would it be possible to have different system settings, or more specifically different Spaces settings, when an external monitor is attatched? Is this supported by default or if not, is there an extension/application that would enable you do this.

The reason being is that I want iTunes to display all the time on my secondary monitor and the only way to do this is to set it to appear in all spaces within the System Preferences. This works perfectly. However, when I disconnect the external monitor; I no longer want it to appear in all spaces.

Can it be done?

 

Yeah it does but maybe I didn't make my issue clear enough; when I disconnect my external monitor, I no longer want the iTunes window to appear in all Spaces.