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eyeing these deals posted on slickdeals but don't know much about support for the Mac pro...

Sapphire Radeon NITRO+ RX 580 4GB $200 + 3 games

PowerColor RED DRAGON Radeon RX Vega 56 $190 +1 game

MSI RX 580 8G V1 8GB $170.99 +3 games

If I must pick one within these three options, I will choose the MSI RX580.

Nitro+ is a 2.2 slot card. This MSI card come with the standard dual slot blower type cooler. Fit better in cMP. The MSI card also has more VRAM.

That Vega card is a better deal in terms of performance. But may suffer from high fan noise issue. Make it not the best option IMO.
 
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You can’t fit a Nitro on a MP5,1 without loosing 2 slots, so it’s a no go for many.

Even with a Pulse, it’s tricky to install in a cMP.

it's maybe old topic, but I have a sapphire nitro rx580 with 8gb card (same form as pulse version), and it fits well in mp5,1 like other cards, why you said have to loose 2 slots?
 
it's maybe old topic, but I have a sapphire nitro rx580 with 8gb card (same form as pulse version), and it fits well in mp5,1 like other cards, why you said have to loose 2 slots?
Because when installing the Nitro+ card in slot 1, it will block the PCIe slot 2 in the process due to it being a slightly taller card
 
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