The U2722DE works best as the center of a workstation, plugged into a laptop. It doesn’t make sense as a single monitor for a desktop. For that, go with a cheaper option with fewer connections, like the S2721D with a similar IPS panel at less than half the price, or innumerable options from other sellers. Likewise, gamers and media junkies can find bigger, faster screens at this price range without input and output flexibility.
But if you want a home base for your powerful laptop, either in your home office or at your desk at work, the U2722DE is an excellent choice.