So when I downloaded OnyX for Lion, I was looking through the options and saw that it had a button for disabling virtual memory. Since my MacBook has 6 GB RAM, I've played around with the idea in my head for a while now, but never got around to actually doing it. I decided to try it and see what happens. It made a noticeable improvement! The computer is now positively zippy, though it wasn't super slow to begin with. My wired memory has gone up significantly, but my active memory has gone down by nearly as much. Overall, it's made a nice improvement. I have yet to run anything significant (Photoshop CS5, FCS2, etc) so I don't know how that will be affected, but for everyday use it's pretty nice. For anyone considering this, do NOT attempt if you have anything less than 4 GB RAM, and it's probably not the best idea if you "just" have 4 GB RAM. This will make your RAM usage go up considerably and if you max out, the OS has nowhere to put the extra RAM content.